Objective: Chronic functional constipation is a frequent condition. The aim of the study\nwas to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM 17938 and magnesium\noxide (MgO) for relieving chronic functional constipation in children. Study design: A prospective,\ndouble-blind, placebo-controlled, randomized, and parallel-group trial was conducted in five\npediatric outpatient clinics in Japan. Sixty patients who were more than six months old and under\nsix years of age with a diagnosis of functional constipation according to Rome IV criteria were\nrandomly divided into three groups: group A (n = 20) received L. reuteri DSM 17938 and lactose\nhydrate as a placebo of MgO; group B (n = 19) received L. reuteri DSM 17938 and MgO; and group\nC (n = 21) received a placebo of L. reuteri DSM 17938 and MgO. Results: All three groups exhibited\nsignificant improvement in defecation frequency in the fourth week compared with the baseline............
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